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KMID : 0900220030100010019
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대한비과학회지
2003 Volume.10 No. 1 p.19 ~ p.22
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Effect of Hypertonic Seawater (Sinomarin(R)) on Mucociliary Clearance in Normal Subjects
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Abstract
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Background and Objectives: The effect of the hypertonic nasal douching solutions on mucociliary clearance was studied to ascertain the effect of hypertonic seawater.
Materials and Methods: Twenty-eight normal subjects were included in a randomized double -blind crossover trial. Hypertonic seawater (3%, Sinomarin(R)) was used as a hypertonic nasal douching solution. In order to determine the effect of hypertonic seawater on nasal mucosa, the mucociliary clearance was measured by the saccharin clearance time (SCT).
Results: The resultant SCT after administration of hypertonic seawater was significantly reduced compared with normal saline (0.9%)(p<0.05).
Conclusion: This results showed that the hypertonic seawater improved mucociliary clearance time in the nasal cavity. The mechanism of this effect is probably brought about by changes in mucus viscoelastic properties.
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